Investigation of the effect of watercress via nuclear factor-E2-related factor-2 pathway on 7,12-dimethylbenz[a]anthracene-induced oxidative damage in rat liver

Aim: Nuclear factor E2-related factor-2 (Nrf2) regulates many cytoprotective antioxidants, and detoxifying enzymes, has been a hopeful approach for chemoprevention of cancer. We researched the chemopreventive impact watercress on DMBA-induced oxidative damage in rat liver via Nrf2/ARE signalling pathway present study. 
 Material Method: Female Wistar albino rats have categorized into three groups. The control was first group, second third groups were administered 7,12-dimethylbenz[a]anthracene (DMBA) (20 mg/kg b.w., i.p.) group given daily doses (250 b.w. Nasturtium officinale R.Br. 4 weeks by oral gavage). Antioxidant phase II detoxification enzyme activities, Nrf2 transcription level liver, serum ALT determined. Also, histopathological analysis performed.
 Results: observed that induces DNA-binding Nrf2. It related to increased activities antioxidant. Our results also demonstrated ameliorated injury.
 Conclusion: data ensured considerable evidence dietary ameliorates DMBA induced toxicity regulating activation which increases expression enzymes.